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Oral product input to the GI tract: GIS an oral product performance technology
Gordon L. Amidon, Yasuhiro Tsume
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 516-520 doi: 10.1007/s11705-017-1658-7
关键词: GIS in vivo predictive dissolution ketoconazole BCS subclassification supersaturation
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
《医学前沿(英文)》 2011年 第5卷 第3期 页码 239-247 doi: 10.1007/s11684-011-0123-0
关键词:
hematopoietic stem cell
hematopoiesis
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 195-203 doi: 10.1007/s11684-012-0189-3
The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.
关键词: ibuprofen solid dispersion physical mixture dissolution anti-inflammatory effect
Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG
《环境科学与工程前沿(英文)》 2014年 第8卷 第2期 页码 151-161 doi: 10.1007/s11783-013-0607-z
关键词: lignocellulosic waste hydrothermal conversion separate dissolution asynchronous hydrolysis mechanism
《环境科学与工程前沿(英文)》 2022年 第16卷 第12期 doi: 10.1007/s11783-022-1586-8
● nZVI, S-nZVI, and nFeS were systematically compared for Cd(II) removal.
关键词: Nano zero valent iron Sulfided zero valent iron FeS Cd(II) immobilization Fe dissolution
Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 384-398 doi: 10.1007/s11705-020-1928-7
关键词: jet-flow high shear mixer solid particle dissolution power consumption characteristics CFD Simulation
Real-time mobile robot teleoperation via Internet based on predictive control
WANG Shihua, XU Bugong, WANG Shihua, ZHOU Yeming, LIU YunHui
《机械工程前沿(英文)》 2008年 第3卷 第3期 页码 299-306 doi: 10.1007/s11465-008-0049-7
关键词: predictive feedback virtual predictive distance synchronization algorithm
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-33 doi: 10.1007/s11705-021-2041-2
关键词: bioactive molecules fluorescent probes in living cells and in vivo review
SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Article
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen
《工程(英文)》 doi: 10.1016/j.eng.2023.05.010
Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease, and aging, resulting in a decline in skeletal muscle function. Therefore, improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders. Owing to their significant role in tissue regeneration, implantation of M2 macrophages (M2Mø) has great potential for improving skeletal muscle regeneration. Here, we present a short-wave infrared (SWIR) fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2Mø transplantation. SWIR fluorescence imaging was employed to track implanted M2Mø in the injured skeletal muscle of mouse models. It is found that the implanted M2Mø accumulated at the injury site for two weeks. Then, SWIR fluorescence imaging of blood vessels showed that M2Mø implantation could improve the relative perfusion ratio on day 5 (1.09 ± 0.09 vs 0.85 ± 0.05; p = 0.01) and day 9 (1.38 ± 0.16 vs 0.95 ± 0.03; p = 0.01) post-injury, as well as augment the degree of skeletal muscle regeneration on day 13 post-injury. Finally, multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle regeneration. These results provide more in vivo details about M2Mø in skeletal muscle regeneration and confirm that M2Mø could promote angiogenesis and improve the degree of skeletal muscle repair, which will guide the research and development of M2Mø implantation to improve skeletal muscle regeneration.
关键词: In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration
《能源前沿(英文)》 doi: 10.1007/s11708-023-0912-6
关键词: model predictive control interconnected data center multi-timescale optimized scheduling distributed power supply landscape uncertainty
The CatMath: an online predictive platform for thermal + electrocatalysis
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 2156-2160 doi: 10.1007/s11705-023-2371-3
关键词: CatMath catalysis volcano activity plots Surface Pourbaix Diagrams online platform
Extended model predictive control scheme for smooth path following of autonomous vehicles
《机械工程前沿(英文)》 2022年 第17卷 第1期 页码 4-4 doi: 10.1007/s11465-021-0660-4
关键词: autonomous vehicles vehicle dynamic modeling model predictive control path following optimization algorithm
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 237-250 doi: 10.1007/s11705-021-2058-6
关键词: nonlinear model predictive control black-box modeling continuous-time system identification machine learning industrial applications of process control
Xiang LI, Yun LUO, Chengtao WANG, Wenguang ZHANG, Yuanchao LI
《机械工程前沿(英文)》 2012年 第7卷 第1期 页码 66-71 doi: 10.1007/s11465-012-0302-y
Electron beam melting process was used to fabricate porous Ti6Al4V implants. The porous structure and surface topography of the implants were characterized by scanning electron microscopy (SEM) and digital microscopy (DM). The results showed that the pore size was around 600 and the porosity approximated to 57%. There was about±50 μm of undulation on implants surfaces. Standard implants and a custom implant coupled with porous sections were designed and fabricated to validate the versatility of the electron beam melting (EBM) technique. After coated with bone-like apatite, samples with fully porous structures were implanted into cranial defects in rabbits to investigate the in vivo performance. The animals were sacrificed at 8 and 12 weeks after implantation. Bone ingrowth into porous structure was examined by histological analysis. The histological sections indicated that a large amount of new bone formation was observed in porous structure. The newly formed bone grew from the calvarial margins toward the center of the bone defect and was in close contact with implant surfaces. The results of the study showed that the EBM produced Ti6Al4V implants with well-controlled porous structure, rough surface topography and bone-like apatite layer are beneficial for bone ingrowth and apposition.
关键词: electron beam melting process implant porous structure bone ingrowth
Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Min Zhang, Jingwen Yang, Wenjing Hua, Zhong Li, Zenghui Xu, Qijun Qian
《医学前沿(英文)》 2019年 第13卷 第1期 页码 32-44 doi: 10.1007/s11684-018-0678-0
Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors.
关键词: immune checkpoint companion diagnosis PD-L1 tumor mutation burden immune score
标题 作者 时间 类型 操作
Oral product input to the GI tract: GIS an oral product performance technology
Gordon L. Amidon, Yasuhiro Tsume
期刊论文
Research progress on hydrothermal dissolution and hydrolysis of lignocellulose and lignocellulosic waste
Yan ZHAO, Wenjing LU, Jiajun CHEN, Xiangfeng ZHANG, Hongtao WANG
期刊论文
Cadmium removal mechanistic comparison of three Fe-based nanomaterials: Water-chemistry and roles of Fe dissolution
期刊论文
Effects of rotor and stator geometry on dissolution process and power consumption in jet-flow high shear
Lin Yang, Wenpeng Li, Junheng Guo, Wei Li, Baoguo Wang, Minqing Zhang, Jinli Zhang
期刊论文
Real-time mobile robot teleoperation via Internet based on predictive control
WANG Shihua, XU Bugong, WANG Shihua, ZHOU Yeming, LIU YunHui
期刊论文
molecule fluorescent probes for simultaneous imaging of two bioactive molecules in live cells and in vivo
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
期刊论文
SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen
期刊论文
Multi-timescale optimization scheduling of interconnected data centers based on model predictive control
期刊论文
machine-learning-based system identification of dynamical systems under control: application towards the model predictive
期刊论文
Fabrication and in vivo evaluation of Ti6Al4V implants with controlled porous structure and complex shape
Xiang LI, Yun LUO, Chengtao WANG, Wenguang ZHANG, Yuanchao LI
期刊论文